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Noribogaine also elevates serotonin concentrations in the brain, a possible clarification for its antidepressive consequences. The sustained presence of noribogaine within the CNS coupled with its agonist get more info activity at opioid receptors may perhaps deliver the self-tapering outcome in opiate-dependent individuals subsequent abrupt discontinuation of opiates. Furthermore, ibogaine has the capacity to alter the expression of numerous proteins, substance P, and click here Mind-derived neurotrophic variable. Noribogaine may be significantly less neurotoxic than ibogaine.Litjens 2016
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